Peter M Blumberg Selected Research

Protein Kinase C

1/2019	Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes.
1/2017	Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol-Lactones as Protein Kinase C Ligands.
12/2016	Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin.
6/2014	Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands.
5/2014	Charge density influences C1 domain ligand affinity and membrane interactions.
1/2011	Fluorescent-responsive synthetic C1b domains of protein kinase Cδ as reporters of specific high-affinity ligand binding.
3/2006	Synthesis and pharmacological evaluation of 8- and 9-substituted benzolactam-v8 derivatives as potent ligands for protein kinase C, a therapeutic target for Alzheimer's disease.
1/2005	Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: real-time analysis using fluorescent ligands and proteins.
9/2003	New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
6/2003	Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Peter M Blumberg Research Topics

Disease

27	Neoplasms (Cancer) 01/2018 - 09/2002
16	Pain (Aches) 01/2021 - 06/2003
8	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 01/2003
6	Hyperthermia 12/2020 - 02/2009
5	Hyperalgesia 01/2020 - 08/2002
5	Neuralgia (Stump Neuralgia) 01/2020 - 08/2014
5	Leukemia 01/2018 - 02/2010
5	Prostatic Neoplasms (Prostate Cancer) 06/2014 - 01/2002
4	Inflammation (Inflammations) 01/2016 - 08/2002
4	Glioma (Gliomas) 06/2008 - 01/2002
3	Infections 07/2003 - 06/2002
2	Lung Neoplasms (Lung Cancer) 01/2019 - 01/2018
2	Hyperplasia 12/2016 - 01/2003
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 03/2006
2	Melanoma (Melanoma, Malignant) 06/2014 - 11/2011
2	Neurogenic Inflammation 04/2013 - 01/2013
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2006 - 02/2003
2	Lymphoid Leukemia 03/2004 - 09/2002
1	Dementia (Dementias) 01/2018
1	Neuroinflammatory Diseases 01/2016
1	Acidosis 01/2016
1	Adenocarcinoma 04/2014
1	Breast Neoplasms (Breast Cancer) 04/2014
1	Disease Progression 01/2013
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2013
1	Colonic Neoplasms (Colon Cancer) 02/2010
1	Carcinoma (Carcinomatosis) 05/2009
1	Lymphoma (Lymphomas) 01/2009
1	Hypersensitivity (Allergy) 07/2008
1	Myotonic Dystrophy (Dystrophia Myotonica) 04/2008
1	Amyloid Plaque 03/2006
1	Sensation Disorders 05/2004

Drug/Important Bio-Agent (IBA)

14	Protein Kinase CIBA 01/2019 - 01/2002
12	Capsaicin (Zostrix)FDA Link 12/2020 - 05/2004
12	Phorbol EstersIBA 01/2019 - 01/2002
10	Proteins (Proteins, Gene)FDA Link 01/2018 - 07/2003
9	LigandsIBA 11/2019 - 01/2003
7	bryostatin 1IBA 12/2016 - 07/2006
6	Analgesics (Analgesic Drugs)IBA 01/2021 - 08/2014
6	Biological ProductsIBA 01/2018 - 01/2003
5	DiglyceridesIBA 05/2014 - 01/2002
4	LactonesIBA 01/2019 - 01/2002
4	BryostatinsIBA 01/2018 - 06/2011
4	CationsIBA 03/2015 - 12/2007
3	Formaldehyde (Formol)FDA Link 01/2021 - 03/2016
3	TRPV1 receptorIBA 01/2013 - 06/2003
3	Protein Kinases (Protein Kinase)IBA 07/2008 - 04/2008
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 03/2006 - 01/2003
2	IsoenzymesIBA 01/2019 - 05/2009
2	phorbolIBA 01/2019 - 12/2016
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2018 - 01/2013
2	Merle 23IBA 12/2016 - 06/2011
2	ras ProteinsIBA 01/2015 - 04/2014
2	Protein Isoforms (Isoforms)IBA 06/2014 - 02/2003
2	Phosphatidylinositols (Phosphatidylinositol)IBA 11/2011 - 08/2002
2	AndrogensIBA 10/2010 - 01/2002
2	TRPV Cation ChannelsIBA 02/2009 - 04/2008
2	Therapeutic UsesIBA 01/2009 - 05/2007
2	Etoposide (VP 16)FDA LinkGeneric 06/2008 - 01/2002
2	Amyloid (Amyloid Fibrils)IBA 03/2006 - 03/2006
2	Tyrosine (L-Tyrosine)FDA Link 06/2005 - 06/2002
2	Growth InhibitorsIBA 03/2004 - 09/2002
1	Opioid Analgesics (Opioids)IBA 11/2019
1	Myristic Acid (Tetradecanoic Acid)IBA 01/2019
1	Acetates (Acetic Acid Esters)FDA Link 01/2019
1	CarcinogensIBA 12/2016
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2016
1	LipidsIBA 01/2016
1	Calcium Channels (Calcium Channel)IBA 01/2016
1	neristatin 1IBA 04/2015
1	Guanine NucleotidesIBA 06/2014
1	Messenger RNA (mRNA)IBA 04/2014
1	Trastuzumab (Herceptin)FDA Link 04/2014
1	Tamoxifen FDA LinkGeneric 04/2014
1	ras Guanine Nucleotide Exchange FactorsIBA 04/2014
1	CalciumIBA 01/2013
1	Guanosine Triphosphate (GTP)IBA 11/2011
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 11/2011
1	AgarIBA 11/2011
1	Epidermal Growth Factor (EGF)IBA 11/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2011
1	Ether (Diethyl Ether)IBA 02/2010
1	beta-chimaerinIBA 09/2009
1	Pharmaceutical PreparationsIBA 07/2009
1	Phosphotransferases (Kinase)IBA 04/2008
1	Local AnestheticsIBA 12/2007
1	QX-314IBA 12/2007
1	Freund's AdjuvantIBA 05/2007
1	Protons (Proton)IBA 05/2007
1	Peptides (Polypeptides)IBA 03/2006
1	Amyloid beta-PeptidesIBA 03/2006
1	ElementsIBA 03/2006
1	CaspasesIBA 06/2005
1	Nerve Growth Factors (Neurotrophins)IBA 05/2004
1	1,4- bis(benzyl)- 8,9- dimethoxy- 4H- benzo(de)(1,6)naphthyridin- 1- iumIBA 03/2004
1	SaltsIBA 03/2004

Therapy/Procedure

5	Induced Hypothermia 12/2020 - 10/2012
4	Therapeutics 04/2013 - 07/2003
2	Drug Therapy (Chemotherapy) 12/2016 - 06/2014
1	Oral Administration 01/2018